(113) Kuhn, P., Thiem, S., Steinert, M., Purvis, D., Lugmayr, V., Treutlein, U., Plobner, L. , Leiser, R.-M., Hust, M. and Dübel, S. (2017). (129) Chung, S.Y., Schöttelndreier, D., Tatge, H., Fühner, V., Hust, M., Beer, L.A. and Gerhard, R. (2018). September 2019 die Norden Vaccines GmbH gegründet. In 1980, the Institute partly moved to the main campus at the TU Braunschweig. whether the antibody is able to inhibit the corona virus from docking to the cells. (87) Kügler, J., Wilke, S. Meier, D., Tomszak, F.,  Frenzel, A. , Schirrmann, T., Dübel, S.,  Garritsen, H.,  Hock, B., Toleikis, L., Schütte, M. and Hust, M. (2015). Suppression of p75 Neurotrophin Receptor Surface Expression with Intrabodies Influences Bcl-xL mRNA Expression and Neurite Outgrowth in PC12 Cells. and Dübel, S. (2018). (22) Schirrmann, T., Hust, M. and Dübel, S. (2007). Human Monoclonal Antibodies: Methods and Protocols, Ed: Steinitz, M.. (73) Kügler, J., Zantow, J., Meyer, T., and Hust, M. (2013). (1999). (105) Miethe, S., Mazuet, C., Liu, Y., Tierney, R., Rasetti-Escargueil, C., Avril, A., Frenzel, A., Thullier, P., Pelat, T., Urbain, R., Fontayne, A., Sesardic, D., Hust, M. and Popoff, M.-R. (2016). Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail. In: Antibody engineering Vol 2, Ed: Kontermann, R. and Dübel, S.. (45) Mollova, S., Retter, I., Hust, M., Dübel, S. and Müller, W. (2010). (102) Kuhn, P., Fühner, V., Moreira, G.M.S.G., Frenzel, A., Miethe, S. and Hust, M. (2016). Pflegedienst Pflege to Hus Herzlich Willkommen. (6)Institute of Toxicology, Hannover Medical School, 30625 Hannover, Germany. (96) Kibat, J., Schirrmann, T., Knape, M.J., Helmsing, S., Meier, D., Hust, M., Schröder, C., Bertinetti, D., Pardes, K., Funk, M., Lages, A., Giese, N., Herberg, F. W., Dübel, S. and Hoheisel, J.D. Trendbericht Biochemie 2018: Menschliche Antikörper für Medikamente. Antibodies play an important role in the fight against the corona virus: they prevent the virus from entering our cells. Der Professor für Biotechnologie an der Technischen Universität Braunschweig ist selbst schon Opfer einer Zecke geworden, die ihn infizierte. Michael Hust weiß, wovon er redet, wenn er über die Borreliose spricht. (60) David, F., Steinwand, M., Hust, M., Bohle, K., Ross, A., Dübel, S. and Franco-Lara, E. (2011). Designing human antibodies by phage display. Karriere an der TU Braunschweig. In Braunschweig, so Hust, kann dies nur das Helmholtz-Zentrum für Infektionsforschung, einer seiner Partner. © Copyright 2015 - 2020 TU Braunschweig | Blogs, Insights into the work of the Corona Antibody Team, Institute of Biochemistry, Biotechnology and Bioinformatics, Institute for Biochemistry, Biotechnology and Bioinformatics, Collaborative Research Centres, Research Groups and Priority Programmes. (84) Hust, M., Frenzel, A., Tomszak, F., Kügler, J. and Dübel, S. (2014). Michael Hust (* 1972 in Oldenburg (Oldb)) ist ein deutscher Biologe und Professor für Biotechnologie an der Technischen Universität Braunschweig. (140) Sellmann, C., Pekar, L., Bauer, C., Ciesielski, E., Krah, S., Becker, S., Toleikis, L., Kügler, J., Frenzel, A., Valldorf,. (2017). TU Braunschweig & Dr. Hust . Generation of recombinant antibodies against toxins and viruses by phage display for Diagnostics and Therapy. Entwicklung von therapeutischen Antikörpern im Reagenzglas. (2018). Kai-Thomas Schneider and Nora Langreder are PhD students at the Institute for Biochemistry, Biotechnology and Bioinformatics at the Technische Universität Braunschweig. Researchers at the Department of Biotechnology of Technische Universität Braunschweig started a research project to develop novel antibody based therapy for coronavirus infections. (107) Zantow, J., Just, S., Lagkouvardos, I., Kisling, S., Dübel, S., Lepage, P., Clavel, T. and Hust, M. (2016). Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus. (124) Russo, G., Theisen, U., Fahr, W., Helmsing, S., Hust, M., Köster R.W. Pyruvate dehydrogenase complex - enzyme 2, a new target for. Generating recombinant antibodies for research, diagnostics and therapy using phage display. Supernatant was harvested after 48 h. Recombinant Antibodies for Diagnostics and Therapy against Pathogens and Toxins generated by Phage Display. Human antibodies neutralizing diphtheria toxin in vitro and in vivo. International Microbiology 6, 33-39, (3) Hust, M., Maiss, E., Jacobsen, H.-J. (2014). The conserved Cys-2232 in Clostridioides difficile toxin B modulates oligomerization and receptor binding. We reached out to Dr. Hust von Technische Universität Braunschweig (Department of Biotechnology). (127) Froude, J.W., Herbert, A.S., Pelat, T., Miethe, S., Zak, S.E., Brannan, J.M., Bakken, R.R., Steiner, A.R., Yin, G., Hallam, T.J., Sato, A.K., Hust, M., Thullier, P. and Dye, J.M. Phage display vectors for the in vitro generation of human antibody fragments. Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV. (133) Kopertekh, L., Meyer, T., Freyer, C. and Hust M. (2019). V., Ruschig, M., Heine, P.A., Rand, U., Klünemann, T., Meier, D., Langreder, N., Steinke, S., Ballmann, R., Schneider, K.-T., Roth, K.D.R., Kuhn, P., Riese, P., Schäckermann, D., Korn, J., Koch, A., Zock-Emmenthal, S., Becker, M., Scholz, M., Moreira, G.M.S.G., Wenzel, E.V., Russo, G., Garritsen, H.S.P., Casu, S., Gerstner, A., Roth, G., Hermann, A., Schirrmann, T., Dübel, S., Frenzel, A., Van den Heuvel, J., Čičin-Šain, L., Schubert, M. and Hust, M. (2020). Fructose 1,6-Bisphosphate Aldolase, a Novel Immunogenic Surface Protein on Listeria Species. Stefan Dübel/TU Braunschweig; HZI/Verena Meier; Hallbauer_Fioretti; Michael Hust/TU Braunschweig; Kai Mattern/Institut für Mikrotechnik/TU Braunschweig; PLRI; Foto: Falk-Martin Drescher / Braunschweig Stadtmarketing GmbH They enjoy working in the consortium, and it shows: “We are happy to be able to make a contribution to helping in the current situation,” says Nora Langreder, and Kai-Thomas Schneider adds: “This includes working on weekends or holidays. Website: https://www.tu-braunschweig.de/bbt/biotech/corat-corona-antibody-team. and von Nickisch-Rosenegk, M. (2016). (88) Becker, M., Felsberger, A., Frenzel, A., Shattuck, W.M.C, Dyer, M., Kügler, J., Zantow, J., Mather, T. and Hust, M. (2015). Persistence of SARS-CoV-2 specific B-and T-cell responses in convalescent COVID-19 patients6-8 months after the infection. Oligopeptide M13 Phage Display in Pathogen Research. A One-Step Process for the Construction of Phage Display scFv and VHH Libraries. Cetuximab (Erbitux). "Wir im Norden ‚können‘ weltweit ausstrahlende Biotech-Hochtechnologie - das möchten wir auch mit dem Namen ausdrücken", kommentierte Mitgründer Professor Michael Hust von der TU Braunschweig. An der TU Braunschweig werden – im Gegensatz zu den bisher meist in Tieren erzeugten Antiseren – rein menschliche Antikörper mithilfe der Antikörperphagendisplay-Technologie entwickelt. Application of M13 Phage Display for Identifying Immunogenic Proteins from Tick (Ixodes scapularis) Saliva. 47 of the best inhibiting antibodies were handed over to the HZI for further testing. C., Jordan, E., El-Ghezal, A., Schirrmann, T., Hust, M. und Jostock, T. (2005). “At the institute we have numerous of these antibody gene libraries. P., Sesardic, D. and Hust, M. (2015). Construction of human naive antibody gene libraries. (109) Noyan, F., Zimmermann, K., Hardtke-Wolenski, M., Knoefel, A., Schulde, E., Geffers, R., Hust, M., Huehn, J., Galla, M., Morgan, M., Jokuszies, A., Manns, M.P., Jaeckel, E. (2017). (2016). Identification of Novel Immunogenic Proteins of Neisseria gonorrhoeae by Phage Display. Microsensor System for Biochemical and Medical Analysis. and Hust, M.. (120) Unkauf, T., Hust, M. and Frenzel, A. (35) Schütte, M., Thullier, P., Pelat, T., Wezler, X., Rosenstock, P., Hinz, D., Kirsch, M.I., Hasenberg, M., Frank, R., Schirrmann, T., Gunzer, M., Hust, M. and Dübel, S. (2009). Stellvertretend für das ganze Corona Antibody Team (CORAT): die TAs, Doktoranden und Postdocs der TU Braunschweig. (93) Rasetti-Escargueil, C., Avril, A., Tierney, R., Bak, N., Miethe, S., Chahboun, S., Mazuet, C., Popoff, M., Thullier, P., Hust, M., Pelat, T. and Sesardic, D. (2015). Validation of the Production of Antibodies in Different Formats in the HEK 293 Transient Gene Expression System. Picture credits: Michael Hust/TU Braunschweig. (74) Frenzel, A., Kügler, J., Wilke, S., Schirrmann, T. and Hust, M. (2014). 5/2011 Habilitation (professorial dissertation, venia legendi for biotechnology), appointed as Privatdozent (PD). (38) Pelat, T., Hust., M. and Thullier, P. (2009). (2012). Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody. Prof. Dr. Michael Hust Technische Universität Braunschweig Institut für Biochemie, Biotechnologie und Bioinformatik Abteilung Biotechnologie Spielmannstraße 7 38106 Braunschweig Tel. (29) Thie, H., Meyer, T., Schirrmann, T., Hust, M. and Dübel, S. (2008). ETH Zürich), M.Arch. Lecturer for molecular biotechnology. In order to find suitable antibody candidates against the corona virus, the team at Carolo-Wilhelmina is working at full speed. Parallelized antibody selection in microtiter plates. (2018). An der TU Braunschweig können solche Antikörper gentechnologisch komplett im Reagenzglas gewonnen werden. Selection Strategies II: Antibody phage display. Efficient production of soluble recombinant single chain Fv fragments by a Pseudomonas putida strain KT2440 cell factory. (16) Jordan, E., Hust, M., Roth, A., Biedendieck, R., Schirrmann, T., Jahn, D. and Dübel, S. (2007). (75) Steinwand, M., Droste, P., Frenzel A., Hust, M., Dübel, S. and Schirrmann, T. (2014). Die TU Braunschweig (Prof. Michael Hust) ist Teil des COVID19-Konsortiums "ATAC" im Rahmen des EU Horizon2020 Corona-Förderprogramms. Antibody Phage Display: Antibody Selection in Solution Using Biotinylated Antigens. (2020). (146) Bertoglio, F., Fühner. In cooperation with the biotechnology company YUMAB, a spin-off of the TU Braunschweig, the Carolo-Wilhelmina researchers have investigated several thousand antibodies. (69) Miethe, S., Meyer, T., Wöhl-Bruhn, S.,  Frenzel. (2016). : 0531 391-5760 “At first we don’t test with the real corona virus, but only with part of the virus’ surface. Die Daten dienen dazu, das Webangebot zu optimieren.Weitere Informationen finden Sie in unserer Datenschutzerklärung. Immunotherapy of Cancer: Methods and Protocols, Ed. An immunochemical in situ approach to detect adaptation processes in the photosynthetic apparatus of diatoms of the Wadden Sea sediment surface layers. Influence of the hydromechanical stress and temperature on growth and antibody fragment production with Bacillus megaterium. “Before Corona, each of us did our own research on his or her own project. In the interview they told us about the search for antibodies at Carolo-Wilhelmina, what antibody libraries are and why teamwork is so important for their research. (79) Trott, M., Weiß, S., Antoni, S., Koch, J., von Briesen, H., Hust, M. and Dietrich, U. and Rhiel, E. (2003). So-called antibody gene libraries contribute to this. When we are ill, our immune system forms antibodies against the pathogens (antigens). But what is the best way to look for it? E.,  Condemine, F., Bottex, C., Vidal, D., Lefranc, M.P., Dübel, S. and Thullier, P. (2007). (61) Zhang, C., Helmsing, S., Zagrebelsky, M., Schirrmann, T., Marschall, A.L.J., Schüngel, M., Korte, M., Hust, M. and Dübel, S. (2012). (51) Meyer, T.,  Stratmann-Selke, J., Meens, J., Schirrmann, T., Gerlach G.F., Frank, R., Dübel, S., Strutzberg-Minder, K. and Hust, M (2011). It works great because we can rely on each other,” says Nora Langreder describing the collaboration. (20) Hust, M., Dübel, S. and Schirrmann, T. (2007). It's current labs are located in the Biocentre and the BRICS. Krumbein and PD Dr. Erhard Rhiel. Yotnda, P.. (48) Dübel, S., Stoevesandt, O., Taussig, M.J. and Hust, M. (2010). (15) Soltes, G., Hust, M., Ng, K.K.Y., Bansal, A., Field, J., Stewart, D.I.H., Dübel, S., Cha, S. and Wiersma, E. (2007). To support the CORAT consortium they have temporarily put their own projects on hold. Wir sind auch dankbar für die rasche Anschubfinanzierung aus dem Land Niedersachsen, und die Förderung durch die Deutsche Herzstiftung e.V., Frankfurt a.M. Viruses 10: 147, (125) Sadana, P., Geyer, R., Pezoldt, J., Helmsing, S., Huehn, J., Hust, M., Dersch, P. and Scrima, A. (2018). (28) Kirsch, M.I., Hülseweh, B., Nacke, C., Rülker, T., Schirrmann, T., Marschall, H.-J., Hust, M. and Dübel, S. (2008). Epitope Mapping by Phage Display. (55) Hust, M., Meyer, T., Voedisch, B., Rülker, T., Thie, H., El-Ghezal, A., Kirsch, M.I., Schütte, M., Helmsing, S., Meier, D., Schirrmann, T. and Dübel, S. (2011). Erfahren Sie mehr über die Kontakte von Wolfgang Niemeier und über Jobs bei ähnlichen Unternehmen. Immune libraries from non-human primates (NHP). (126) Burke, C.W., Froude, J.W., Miethe, S., Hülseweh, B., Hust, M. and Glass, P.J. Phage display derived therapeutic antibodies. Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile. www.bbt.tu-bs.de/Biotech, Technische Universität Braunschweig “The next step will be clinical trials, which hopefully can start in autumn,” says Stefan Dübel. A transplant immunome deep sequencing and screening platform defines a unique targetable epitope fingerprint of multiple myeloma. 12/2014 Appointed as professor for biotechnology (außerplanmäßiger Professor). Selection of recombinant antibodies from antibody gene libraries. Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig Postfach: 38092 Braunschweig Telefon: +49 (0) 531 391-0. Prof. Dr. Michael Hust Technische Universität Braunschweig Institut für Biochemie, Biotechnologie und Bioinformatik Abteilung Biotechnologie Spielmannstraße 7 38106 Braunschweig Tel. since 12/2002 Group leader at the Institut für Biochemie und Biotechnologie, Abteilung Biotechnologie, Technische Universität Braunschweig headed by Prof. Dr. Stefan Dübel. (131) Fühner, V., Heine, P.A., Zilkens, K., Meier, D., Roth, K.D.R., Moreira, G.M.S.G., Hust, M. and Russo, G. (2019). (64) Meyer, T.,  Schirrmann, T., Frenzel, A., Miethe, S., Stratmann-Selke, J., Gerlach, G.F., Strutzberg-Minder, K., Dübel, S., and Hust, M. (2012). Curriculum vitae 10/1993 - 7/1999 Studies of Biology at the Carl-von-Ossietzky Universität, Oldenburg. (2016). The consortium develops neutralizing antibodies against the SARS-CoV-2 virus. (128) Beer, L.A., Tatge, H., Schneider, C., Ruschig, M., Hust, M., Barton, J., Thiemann, S., Fühner, V., Russo, G. and Gerhard, R. (2018). ORFeome Phage Display. Development of recombinant antibodies for biodefense using phage display. Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library. “Human monoclonal antibodies, i.e. Gegen fiese Krabbelviecher, genauer Zecken der Gattung Ixodes, entwickeln Forscher der TU Braunschweig eine Impfung.Für anschließende klinische Studien haben Biologe Michael Hust, Professor an der TU, und Biotechnologin Viola Fühner, Postdoc ebendort, gemeinsam mit weiteren Mitstreitern die Firma Norden Vaccines gegründet. Identification of immunogenic polypeptides from a Mycoplasma hyopneumoniae genome library by phage display. Technische Universität Braunschweig In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S.. (42) Pelat, T., Hust, M. and Thullier, P. (2010). 38106 Braunschweig Schlüsselreagenzien für den nächsten großen Schritt. (81) Fuchs, M., Kämpfer, S., Helmsing, S., Spallek, R., Oehlmann, W., Prilop, W., Frank, R., Dübel, S., Mahavir, S. and Hust, M. (2014). (2017). (62) Frenzel, A., Fröde, D., Meyer, T., Schirrmann, T. and Hust, M. (2012). www.bbt.tu-bs.de/Biotech, Scientists and industrial partners in the Corona Antibody Team (CORAT consortium) are researching a passive immunisation therapy against the corona virus. Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B. (13) Hust, M., Meysing, M, Schirrmann, T., Selke, M., Meens, J., Gerlach, G.-F. and Dübel, S. (2006). (95) Tomszak, F., Weber, S., Zantow, J., Schirrmann, T., Hust, M. and Frenzel, A. A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to known RBD mutations. (27) Kügler, J., Nieswandt, S., Gerlach, G.F., Meens, J., Schirrmann, T. and Hust, M. (2008). Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality. Expression of recombinant Antibodies. BDA Braunschweig geht zurück an die Uni - Am Institut für Tragwerksentwurf (ITE) der TU Braunschweig wird unter der Leitung von Univ. The binary toxin CDT of Clostridium difficile as tool for intracellular delivery of bacterial glucosyltransferase domains. (26) Thie, H., Schirrmann, T., Paschke, M., Dübel, S. and Hust, M. (2008). In addition, the team has also created such libraries from the blood of cured corona patients because the probability of finding a suitable antibody is even greater in such cases. In: Handbook of Therapeutic Monoclonal Antibodies: From Bench to Clinic, Ed: An, Z. and Strohl, W.. (32) Jordan, E., Al-Halabi, L., Schirrmann, T. and Hust, M. (2009). (12) Konthur, Z., Hust, M. and Dübel, S. (2005). Die Antikörperfabrik: Antikörper für jedes Protein. The work now feels like a doctoral thesis on a much larger scale and in less time, which we are all doing together as a team. and Hust, M.. (118) Avril, A., Miethe, S., Hust, M. and Pelat, T. (2018). and Hust, M.. (119) Russo, G., Meier, D., Helmsing, S., Wenzel, E., Oberle, F., Frenzel, A. and Hust, M. (2018). Picture credits: Michael Hust/TU Braunschweig. ➜ Research Centers: The research profile of the TU Braunschweig is characterized by several interdisciplinary and cross-faculty research networks, which are organized as centers. Multimerization domains for antibody phage display and antibody production. C., Jordan, E., El-Ghezal, A., Schirrmann, T., Hust, M. und Jostock, T. (2005). Construction of Human Immune and Naive scFv Libraries. They have been working in the Corona Antibody Team (CORAT) for several months. (33) Hust, M., Thie, H., Schirrmann, T. and Dübel, S. (2009). Towards "proteome scale" antibody selections using phage display. Phage display, Ed: Lim, T.S. Journal of Virological Methods 106, 225-233, (2) Hust, M., Krumbein, W.E. (39) Schirrmann, T., Menzel, C., Hust, M., Prilop, J., Jostock, T. and Dübel, S. (2010). (2013). m.hust@tu-braunschweig.de. Braunschweiger Forscher gehen den Zecken an den Kragen Jüngste Ausgründung aus der TU Braunschweig Wissenschaftler aus Braunschweig haben heute, am 11. Rise and fall of an anti-MUC1 specific antibody. Kai-Thomas Schneider adds: “We have all learned a lot and have grown together as a team. (94) Unkauf, T., Miethe, S. Fühner, V., Schirrmann, T., Frenzel, A. and Hust, M. (2016). (122) Moreira, G.M.S.G., Fühner, V. and Hust, M. (2018). (145) Bertoglio, F., Meier, D., Langreder, N., Steinke, S., Rand, U., Simonelli, L., Heine, P. A., Ballmann, R., Schneider, K.-T., Roth, K. D. R., Ruschig, M., Riese, P., Eschke, K., Kim, Y., Schaeckermann, D., Pedotti, M., Kuhn, P., Zock-Emmenthal, S., Wöhrle, J., Becker, M., Grashoff, M., Wenzel, E. V., Russo, G., Kröger, A., Brunotte, L., Ludwig, S., Fühner, V., Krämer, S. D., Dübel, S., Varani, L., Roth, G., Cicin-Sain, L., Schubert, M., and Hust, M. (2020) SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. Novel human recombinant antibodies against Mycobacterium tuberculosis antigen 85B. Production systems for recombinant antibodies. Das Corat wurde von Stefan Dübel und Michael Hust (TU Braunschweig) zusammen mit Gundram Jung (Universität Tübingen) initiiert und ist mittlerweile auf ein Konsortium von 40 Wissenschaftlern und Ärzten aus akademischen Institutionen und der Industrie … The two have been pursuing their doctorate at the Institute for Biochemistry, Biotechnology and Bioinformatics for about a year. and Rhiel, E. (1999). (8) Kirsch, M., Zaman, M., Meier, D., Dübel, S. and Hust, M. (2005). In addition, the team has also created such libraries from the blood of cured corona patients because the probability of finding a suitable antibody is even greater in such cases. Phage display, Ed: Lim, T.S. Vertical migration behaviour of diatom assemblages of Wadden Sea sediments (Dangast/Germany): A study using Cryo-scanning electron microscopy. Recombinant VHHA6 cDNA was cloned into the pCMX expression vector (contributed by M. Hust, TU Braunschweig), which encodes an optimized human IgG1 Fc domain. (34) Pelat, T., Hust, M., Hale, M., Lefranc, M.-P., Dübel, S. and Thullier, P. (2009). First lab space was located in the GBF (National Research Centre for Biotechnology, Braunschweig, now: Helmholtz Centre for Infection Reserach). (47) Naseem, S., Meens, J., Jores, J., Heller, M., Dübel, S., Hust, M. and Gerlach, G.F. (2010). Phage display-based identification and potential diagnostic application of novel antigens from Mycoplasma mycoides subsp. A., Schirrmann, T., Dübel, S. and Hust, M. (2013). Massensensitives Sensor-Fließsystem zur CRP-Diagnostik. (85) Miethe, S., Pelat, T., Avril, A., Popoff, M., Molgo, J., Rasetti‑Escargueil, C., Fontayne, A., Korkeala, H., Thullier, P., Sesardic, D. and Hust, M. (2014). Trends in Biotechnology 22, 8-14, (4) Meyer, T., Hust, M., Marquardt, J., Krumbein, W.E. (68) Bertz, A., Wöhl-Bruhn, S., Miethe, S., Tiersch, B., Koetz, J., Hust, M., Bunjes, H. and Menzel, H. (2013). Phone: +49 531 391-5731 If we come into contact with a known antigen again, the immune system can react stronger and faster than at first contact. 1 Job ist im Profil von Wolfgang Niemeier aufgelistet. Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody. Construction of macaque immune libraries. Discovery of Leptospira spp. (2018). (37) Thie, H., Binius, S., Schirrmann, T., Hust, M. and Dübel, S. (2009). Harald Kloft und Juniorprofessor Dr. (sc. (63) Rülker, T., Voß, L., Thullier, P., O'Brien, L.M., Pelat, T., Perkins, S.D., Langemann, C., Schirrmann, T., Dübel, S., Marschall, H.-J., Hust, M. and Hülseweh, B. and Hust, M.. (121) Zantow, J., Moreira, G.M.S.G., Dübel, S. and Hust, M. (2018. Ihr Ziel ist es, einen universellen Impfstoff gegen von … (71) Jäger, V.,  Büssow, K., Wagner, A., Weber, S., Hust, M., Frenzel, A. and Schirrmann, T. (2013). Heterologe Expression von rekombinanten Proteinpharmazeutika. Email: m.hust@tu-braunschweig.de (123) Dübel, S., Hust, M., Kügler, J., Kuhn, P., Frenzel, A., Krah, S. and Zielonka, S. (2018). Their blueprint is anchored in the immunological memory. Obtention and engineering of non-human primate (NHP) antibodies for therapeutics. (92) Miethe, S., Rasetti-Escargueil, C., Avril, A., Liu, Y., Chahboun, S., Korkeala, H., Mazuet, C., Popoff, M.-R., Pelat, T., Thullier. (103) Frenzel, A., Schirrmann, T. and Hust, M. (2016). (80) Marschall, A.L.J., Zhang, C., Frenzel, A., Schirrmann, T., Hust, M., Perez, F. and Dübel, S (2014). (52) Schirrmann, T., Meyer, T., Schütte, M., Frenzel, A., and Hust, M. (2011). More than 30 scientists and doctors from academic institutions and industry are now involved in the consortium. Sehen Sie sich das Profil von Wolfgang Niemeier auf LinkedIn an, dem weltweit größten beruflichen Netzwerk. Anreise (25) Schirrmann, T., Al-Halabi, L., Dübel, S. and Hust, M. (2008). Recombinant antibody fragments allow repeated measurements of C-reactive protein with a quartz crystal microbalance immunosensor. A Multinational Consortium for the Development of Therapeutic Antibodies to Tier 1 Bioterrorism Agents: Protective scFv-Fc Antibody against Marburg Virus derived from Macaque Immune Library. Construction of human antibody gene libraries and selection of antibodies by phage display. Aufbauend auf den Forschungsergebnissen des Konsortiums hat das Biotechnologieunternehmen YUMAB, eine Ausgründung der TU Braunschweig, die CORAT Therapeutics GmbH gegründet. Phage display-derived human antibodies in clinical development and therapy. Kai-Thomas Schneider and Nora Langreder arrived in a good mood and with mouth and nose protection for our conversation via video conference. (144) Laureano, A.F.S., Zani, M.B., Sant'Ana, A.M., Tognato, R.C., Lombello, C.B., do Nascimento, M.H.M., Helmsing, S., Fühner, V., Hust, M. and Puzer, L (2020). (46) Steinwand, M., Jordan, S. and Hust, M. (2010). (2016). (17) Hust, M., Jostock, T., Menzel, C., Voedisch, B., Mohr, A., Brenneis, M., Kirsch, M.I., Meier, D. and Dübel, S. (2007). They were obtained from human blood in pre-Corona times and, put simply, contain the information for the basic construction of practically all antibodies that the human species can produce,” explains Kai-Thomas Schneider. Jacobsen and Dr. Thomas Reinard. Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor. Die Grundlage für ihre Arbeit sind die neutralisierenden Antikörper gegen Covid-19, die die Technische Universität Braunschweig gemeinsam mit dem Biotechnologieunternehmen Yumab GmbH im Corat Konsortium entwickelt hat.

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